To resolve this issue or to delete this file do the following. You might have to download handle.exe or processexplorer.exe will help.
Run handle.exe > output.txt
Find out the process id and the handle number used.
For example in the following output file process id is 8 and the handle to be closed is 218
So run handle -c 218 -p 8
How to run handle -c example:
C:\handle>handle -c 218 -p 8
Handle v3.46
Copyright (C) 1997-2011 Mark Russinovich
Sysinternals - www.sysinternals.com
218: File (---) C:\NBU_VSP_Cache\_vxfiVspCacheFile_1.VSP
Close handle 218 in System (PID 8)? (y/n) Y
Handle closed.
Now you can delete the file.
Handle output file:
Handle v3.46
Copyright (C) 1997-2011 Mark Russinovich
Sysinternals - www.sysinternals.com
------------------------------------------------------------------------------
System pid: 8 NT AUTHORITY\SYSTEM
EC: File (RW-) \Device\Mup
15C: File (-W-) C:\pagefile.sys
218: File (---) C:\NBU_VSP_Cache\_vxfiVspCacheFile_1.VSP
250: File (RW-) C:\FTP